HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline-8-carbaldehyde → 1-(6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline-8-carbaldehyde | HCID 86759442 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinolin-8-yl)-ethanol | HCID 22719821 | — |
Reaction Steps
Following General Procedure C, 6-isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline-8-carbaldehyde (Intermediate 8, 4.54 g, 19.2 mmol) and a solution of methyl magnesium bromide (3M, 16 ml, 47.9 mmol) in THF were reacted to give the title compound as a light yellow oil after purification by column chromatography using 5% ethyl acetate in hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734193B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-6b67bcb2ab5449c29983a9f3fa7ac79e |
| Source note | uspto-grants-2004_05 |