HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl 2-fluoro-2-phosphonoacetate → (E)-3-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-enoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl 2-fluoro-2-phosphonoacetate | HCID 2734865 | — |
| Reactant | 1-(1-Ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-propan-1-one | HCID 22719825 | — |
| Product | (E)-3-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-enoic acid ethyl ester | HCID 69898934 | — |
Reaction Steps
Following General Procedure E, triethyl-2-fluoro-2-phosphonoacetate (15.1 g, 62.3 mmol) and 1-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-1-propanone (Intermediate 13, 4.48 g, 15.6 mmol) were reacted to give the title compound as bright yellow oil after purification by flash chromatography (SiO2, 2:98 ethyl acetate:hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734193B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-6e2fdf441ff34f8693418e96f8f48c38 |
| Source note | uspto-grants-2004_05 |