反应详情

Following General Procedure F, (E)-3-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-enoic acid ethyl ester (Intermediate 16, 2.37 g, 9.08 mmol) and a 1 M solution of diisobutylalluminum hydride in hexanes (36.3 ml, 36.3 mmol) were reacted to give the title compound as light yellow oil after purification by flash chromatography (SiO2, first eluted with 5:95 ethyl acetate:hexane, followed by 1:9 ethyl acetate:hexane).