HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl morpholine oxide → (E)-3-(1-Ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-enal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | (E)-3-(1-Ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-en-1-ol | HCID 69897013 | — |
| Product | (E)-3-(1-Ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-enal | HCID 86759443 | — |
Reaction Steps
Following General Procedure G, (E)-3-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-2-fluoro-pent-2-en-1-ol (Intermediate 19, 2.45 g, 6.28 mmol) and N-methylmorpholine N-oxide (1.73 g, 12.6 mmol) were reacted to give the title compound as a bright yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734193B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-5ec7e1d42efd4dc8ab3216c22da2b8b8 |
| Source note | uspto-grants-2004_05 |