Sodium Hydroxide → HCID 60086016, compound

Participants

Reaction Steps

Following General Procedure I, (2E,4E,6E)-7-(1-ethyl-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoic acid ethyl ester (Compound 25, 630 mg, 14.3 mmol) was hydrolyzed with NaOH to yield the title compound as a yellow solid after purification by column chromatography (silica, first using 100% hexane, followed by 5:95 ethyl acetate:hexane, then 1:1 ethyl acetate:hexane) to yield a yellow oil. The resulting yellow oil was recrystallized from acetonitrile.

Provenance & Evidence