Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-methylpyridine-4-carboxylic Acid Hydrochloride → N-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-methyl-isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-methylpyridine-4-carboxylic Acid Hydrochloride | HCID 2762824 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine | HCID 22015735 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-methyl-isonicotinamide | HCID 22719556 | — |
반응 단계
From 2-methyl-isonicotinic acid hydrochloride, HATU and N-diethylisopropylamine in THF, then treatment with 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine in dioxane and DMF. ES-MS m/e (%): 406 (M+Na+, 46), 384 (M+H+, 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06734179B2 |
| 출처 데이터셋 | uspto-grants-2004_05 |
| ORD ID | ord-9359993c4f514f6e9a1ea2dc530caded |
| 출처 메모 | uspto-grants-2004_05 |