HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1582112Generated: October 26, 2026
tert-Butyl 4-(tributylstannyl)-3,6-dihydropyridine-1(2H)-carboxylate → HCID 86588830, compound
https://huagongshe.com/reaction/1582112
Participants
| Role | Name | HCID | Charge |
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| Reactant | tert-Butyl 4-(tributylstannyl)-3,6-dihydropyridine-1(2H)-carboxylate | HCID 12094207 | — |
| Reactant | (7-Iodo-4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester | HCID 60117385 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86588830 | HCID 86588830 | 36.2% |
Reaction Steps
To a stirred solution of 2.2 g (0.006 Mol) (7-iodo-4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester in 60 ml DMF were added 3.4 g (0.007 Mol) 4-tributylstannanyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester, 0.424 g (0.001 Mol) PdCl2(PPh3)2 and 0.12 g (0.001 Mol) CuI. The mixture was heated at 100° C. for 19 h and then concentrated in vacuo. Flash chromatography (ethyl acetate/hexane 1:1) afforded 0.91 g (36%) 4-(4-methoxy-2-methoxycarbonylamino-benzothiazol-7-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester as a light yellow foam. ES-MS m/e (%): 362 ([M+H]+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06734179B2 |
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| Source dataset | uspto-grants-2004_05 |
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| ORD ID | ord-43f2420cf8d84840862893d406a74fca |
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| Source note | uspto-grants-2004_05 |
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