反应详情

To a solution of 0.04 g (0.94 mMol) of N-[7-(1-acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide in 2.0 ml of methanol 10.0 mg of Pd/C (10%) were added. This reaction mixture was hydrogenated at 60° C. for 6 h, then filtered and evaporated to dryness in vacuo to yield 0.021 g (52%) N-[7-(1-acetyl-piperidin-4-yl)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide as a white solid. F.p.: 225-233° C.

1. filtrationfiltered
2. customevaporated to dryness in vacuo