反应详情

0.130 g (0.27 mMol) 4-{4-methoxy-2-[(morpholine-4-carbonyl)-amino]-benzothiazol-7-yl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester were dissolved in 3 ml 2.5 M HCl/MeOH and heated to reflux for 1.5 h. The reaction mixture was concentrated in vacuo and taken up in 3 ml isopropanol. The suspension formed was filtered and the material on the filter was washed with diethyl ether and dried in vacuo. One obtained 95 mg (84%) morpholine-4-carboxylic acid [4-methoxy-7-(1,2,3,6-tetrahydro-pyridin-4-yl)-benzothiazol-2-yl]-amide hydrochloride (1:1) as an off-white solid. ES-MS m/e (%): 375 ([M+H]+, 100).

1. temperatureheated
2. temperatureto reflux for 1.5 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. customThe suspension formed
5. filtrationwas filtered
6. washthe material on the filter was washed with diethyl ether
7. customdried in vacuo