Tetrahydrofuran → HCID 86588844, compound

Participants

Reaction Steps

To a solution of 0.39 g (0.73 mMol) of 4-{2-[(2-chloro-6-methoxy-pyridine-4-carbonyl)-amino]-4-methoxy-benzothiazol-7-yl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 16.0 ml of methanol and 16.0 ml THF 100 mg of Pd/C (10%) and 0.15 ml triethyl amine were added. The reaction mixture was hydrogenated at 60° C. for 6 h, then filtered and evaporated to dryness in vacuo. The residue was subjected to column chromatography (ethyl acetate/hexane 1:1) to yield 0.110 g (30%) 4-{4-methoxy-2-[(2-methoxy-pyridine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester as a white foam. ES-MS m/e (%): 499 ([M+H]+, 100).

Provenance & Evidence