Tetrahydrofuran → 4-{4-Methoxy-2-[(morpholine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

To a solution of 0.13 g (0.274 mMol) of 4-{4-Methoxy-2-[(morpholine-4-carbonyl)-amino]-benzothiazol-7-yl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in 6.0 ml of methanol and 6.0 ml of tetrahydrofuran 80.0 mg of Pd/C (10%) were added. The reaction mixture was hydrogenated at 60° C. for 8 h, then filtered and evaporated to dryness. The residue was subjected to column chromatography on silica gel (ethyl acetate) to yield 0.048 g (37%) 4-{4-Methoxy-2-[(morpholine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester as a colorless foam. ES-MS m/e (%): 477 ([M+H]+, 100).

Provenance & Evidence