反应详情

0.45 g (0.094 mMol) 4-{4-Methoxy-2-[(morpholine-4-carbonyl)-amino]-benzothiazol-7-yl}-piperidine-1-carboxylic acid tert-butyl ester were dissolved in 2 ml 2.5 M HCl/MeOH and heated to reflux for 1.5 h. The reaction mixture was concentrated in vacuo and taken up in 5 ml isopropanol. The suspension formed was filtered and the material on the filter was washed with diethyl ether and dried in vacuo. One obtained 26 mg (67%) morpholine-4-carboxylic acid (4-methoxy-7-piperidin-4-yl-benzothiazol-2-yl)-amide hydrochloride (1:1) as a white solid. F.p.: 314-315° C.

1. temperatureheated
2. temperatureto reflux for 1.5 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. customThe suspension formed
5. filtrationwas filtered
6. washthe material on the filter was washed with diethyl ether
7. customdried in vacuo