HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 10173142, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2,6-Di-tert-butyl-4-methylphenol | HCID 31404 | — |
| Reactant | Allyltributylstannane | HCID 90628 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 2-Bromo-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide | HCID 22719538 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10173142 | HCID 10173142 | — |
Reaction Steps
From 2-bromo-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide with allyltri-n-butyltin, bis(triphenylphosphine)palladium(II) chloride, triphenylphosphine, lithium chloride and 2,6-di-tert-butyl-para-cresol in DMF, then hydrogenation with palladium on charcoal in dichloromethane and methanol. ES-MS m/e (%): 412 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734179B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-43587a47ab484bbfa6becf9b5857dc7c |
| Source note | uspto-grants-2004_05 |