HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoic Acid → 4-Fluoro-N-[4-methoxy-7-(tetrahydro-pyran-2-yl)-benzothiazol-2-yl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoic Acid | HCID 9973 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-Methoxy-7-(tetrahydro-pyran-2-yl)-benzothiazol-2-ylamine | HCID 22719534 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Fluoro-N-[4-methoxy-7-(tetrahydro-pyran-2-yl)-benzothiazol-2-yl]-benzamide | HCID 10172774 | — |
Reaction Steps
From 4-fluorobenzoic acid, HATU and N-diethylisopropylamine in THF, then treatment with 4-methoxy-7-(tetrahydro-pyran-2-yl)-benzothiazol-2-ylamine in dioxane and DMF. ES-MS m/e (%): 387 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734179B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-4ba314efe4364e6db3eb21ae5d779a64 |
| Source note | uspto-grants-2004_05 |