HCID 10069989, compound → HCID 66884727, compound

Participants

Reaction Steps

Pd/C (6 mg, 10 wt %) was added to a solution of (4-{(R)-2-[(E)-4-(3-chlorophenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid methyl ester (59 mg, 0.14 mmol) in methanol (2 mL). The reaction mixture was evacuated and refilled with hydrogen (3×) then stirred at rt under a balloon of hydrogen for 3.5 h. The reaction mixture was filtered through celite, washing with methanol (5 mL). The filtrate was concentrated in vacuo to afford 59 mg (99%) of (4-{(R)-2-[4-(3-Chlorophenyl)-3-oxo-butyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid methyl ester.

Provenance & Evidence