Hydrochloric Acid → HCID 66884852, compound

Participants

Reaction Steps

Sodium borohydride (4.1 mg, 0.11 mmol) was added to a solution of (4{(R)-2-[4-(3-Chlorophenyl)-3-oxo-butyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid methyl ester (44 mg, 0.11 mmol) in CH2Cl2 (1 mL) at rt. Methanol (3 drops) was added and the reaction was stirred at rt for 4.5 h. Aqueous HCl (0.5 M, 5 mL) was added and the mixture was extracted with CH2Cl2 (2×8 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (0%→3% MeOH/CH2Cl2) to afford 9.1 mg (21%) of (4-{(R)-2-[4-(3-chlorophenyl)-3-hydroxy-butyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid methyl ester.

Provenance & Evidence