Hydrochloric Acid → HCID 66884698, compound

Participants

Reaction Steps

Aqueous lithium hydroxide (1.0 N, 0.04 mL) was added to a solution of (4-{(R)-2-[(E)-4-(3-chlorophenyl)-3-hydroxy-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid methyl ester (16 mg, 0.039 mmol) in THF (0.25 mL) at rt. After 1 h, aqueous HCl (0.5 N, 3 mL) was added and the mixture was extracted with ETOAc (2×5 mL). The combined organic phase was washed with brine (10 mL), dried (Na2SO4), filtered and concentrated in vacuo to afford 15 mg (97%) of (4-{(R)-2-[(E)-4-(3-chlorophenyl)-3-hydroxy-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-butoxy)-acetic acid.

Provenance & Evidence