Pyridine → HCID 178427272, compound

Participants

Reaction Steps

A sulfur trioxide-pyridine complex (2.51 g, 15.8 mmol) was added to a solution of N-(aminoiminomethyl)-1,4-dimethyl-7-hydroxy-1H-indole-2-carboxamide methanesulfonate (1.80 g, 5.26 mmol) in pyridine (20 ml), and the resulting mixture was stirred at room temperature for 16.5 hours. The solvent was distilled off under reduced pressure and water was added to the residue. Subsequently, diethyl ether was added thereto, and the solid precipitated was collected by filtration and washed with methanol to obtain 1.43 g of 2-[[[amino(imino)methyl]amino]carbonyl]-1,4-dimethyl-1H-indol-7-yl hydrogen sulfate.

Provenance & Evidence