HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyraldehyde → HCID 21985214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(1H-Benzo[d]imidazol-2-yl)methyl]-N-(4-(aminomethyl)-benzyl)-5,6,7,8-tetrahydroquinolin-8-amine | HCID 21985008 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21985214 | HCID 21985214 | 25% |
Reaction Steps
Isobutyraldehyde (0.1 mL, 1.1 mmol) was condensed with N′-(1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine (152 mg, 0.382 mmol) in dry CH3OH (5 mL) for 17 h and the resultant imine was reduced with NaBH4 (81 mg, 2.14 mmol) for 1 h (see General Procedures A and B). Purification of the crude product by radial chromatography (2 mm TLC plate, 50:1:1 CH2Cl2/CH3OH/NH4OH) gave the free amine (43 mg, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734191B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-f1a7eea8064e475883b8aed0e60e1adc |
| Source note | uspto-grants-2004_05 |