反应详情

To a solution of methyl-4-(oxazol-2-yl)-benzoate (0.203 g, 1 mmol) in CH2Cl2 (10 mL) 0° C. was added DIBAL-H (4 mL of a 1.0M solution in dichloromethane, 4 mmol) over 10 min. The resultant solution was stirred at 0° C. for 2 h then quenched with an aqueous saturated solution of sodium potassium tartrate (20 mL) and the biphasic mixture stirred rapidly for 60 min. The phases were separated and the aqueous layer extracted with CH2Cl2 (3×10 mL). The combined organic fractions were dried (Na2SO4), filtered, concentrated and purified by chromatography on silica gel (10:1 CH2Cl2/MeOH) to afford the title alcohol (0.156 g, 89%). 1H NMR (CDCl3) δ3.42 (t, 1H, J=6.0 Hz (OH)), 4.77 (s, 2H, J=6.0 Hz), 7.24 (s, 1H), 7.47 (d, 2H, J=7.8 Hz), 7.71 (s, 11H), 8.05 (d, 2H, J=7.8 Hz).

1. customthen quenched with an aqueous saturated solution of sodium potassium tartrate (20 mL)
2. customThe phases were separated
3. extractionthe aqueous layer extracted with CH2Cl2 (3×10 mL)
4. dry with materialThe combined organic fractions were dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified by chromatography on silica gel (10:1 CH2Cl2/MeOH)