HCID 54399474, compound → 5(S)Isoxazol-3-ylaminomethyl-3-(4-(2-methylimidazol-1-yl)-3-fluorophenyl)oxazolidin-2-one

Participants

Reaction Steps

Using essentially the technique of Example 8, but starting from 3-(4-(2-methylimidazol-1-yl)-3-fluorophenyl)-5(R)-(N-(t-butoxycarbonyl)isoxazol-3-ylaminomethyl)oxazolidin-2-one (510 mg, 1.12 mM), and isolating finally by extraction into dichloromethane gave title product (358 mg ). NMR (DMSO-d6) δ: 2.16 (s, 3H ); 3.46 (t, 2H); 3.87 (dd, 1H); 4.22 (t, 1H); 4.93 (m, 1H); 6.01 (d, 1H); 6.53 (t, 1H); 6.93 (d, 1H); 7.21 (d, 1H); 7.46 (dd, 1H); 7.55 (t, 1H); 7.75 (dd, 1H); 8.39 (d, 1H). MS (ESP): 358 (MH+) for C17H16FN5O3

Provenance & Evidence