反应详情

温度

-10 °C

A stirred suspension of 2-bromo-3-hydroxy-4-methoxybenzaldehyde (commercially available, 24 g, 104 mmol) and K2CO3 (29.4 g, 213 mmol) in DMF (125 ml) was cooled to −10° C. Dimethylsulfate (9.6 ml, 102 mmol) was added, the reaction was warmed to room temperature and stirred overnight. The resulting solution was quenched with water (375 ml) and the resulting suspension stirred overnight. The resulting suspension was filtered and the solid dried in vacuo at 50° C. to give 23.1 g of the subtitle product (91%).

1. temperaturethe reaction was warmed to room temperature
2. customThe resulting solution was quenched with water (375 ml)
3. stirringthe resulting suspension stirred overnight
4. filtrationThe resulting suspension was filtered
5. customthe solid dried in vacuo at 50° C.