Hydrazine hydrate (1:1) → HCID 22721250, compound

Participants

Reaction Steps

To a stirred solution of tert-Butyl 3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (70.0 mg, 0.187 mmol) in EtOH (1.9 mL) was added hydrazine monohydrate (19.0 mg, 0.375 mmol) at room temperature and the mixture was refluxed for 1 h. After cooling, the precipitates formed were filtered off. The filtrate was evaporated in vacuo and the residue was purified by preparative TLC (SiO2, 20×20 cm, 1 mm, CH2Cl2/MeOH/aqueous NH3=92/6/2) to afford a product (21.4 mg, 42%) as a white solid.

Provenance & Evidence