反应详情

To homopiperazine (5 g, 0.05 mol) in acetonitrile (30 mL), 3.4-difluoronitrobenzene (3.17 g, 0.02 mol) was added and the reaction mixture was heated to reflux for 4 hrs. Then the solvent was evaporated and the residue taken in EtOAc and washed with water and brine solution. The EtOAc layer was dried over anhyd Na2SO4 and evaporated in vacuo. The residue was digested with ether-hexane (1:20), decanted and dried in vacuo to get 3.7 g of final product.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 4 hrs
3. customThen the solvent was evaporated
4. washwashed with water and brine solution
5. dry with materialThe EtOAc layer was dried over anhyd Na2SO4
6. customevaporated in vacuo
7. customdecanted
8. customdried in vacuo