Benzyl chloroformate → HCID 22291160, compound

Participants

Reaction Steps

To 3-Fluoro-4-(N-tert-butoxycarbonylhomopiperazinyl)aniline (2.6 g, 8.4 mmol) in THF (25 ml) cooled to 5° C., sodium bicarbonate (0.85 g 10.1 mmol), was added and then benzylchloroformate (1.72 g, 10 mmol) was added dropwise. The reaction mixture was stirred for 18 hrs. at R.T. and then filtered. The filtrate was evaporated in vacuo. The residue was dissolved in dichloromethane and washed with saturated sodium bicarbonate solution and brine water. The organic layer was dried over anhyd Na2SO4 and evaporated in vacuo to give 5.04 g of final product.

Provenance & Evidence