HCID 22717495, compound → HCID 135744189, compound

HRID 1582519Notes

Reaction equation

HRID 1582519 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][Si:26]([CH3:34])([CH3:33])[CH2:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[CH:17][N:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C.C(OCC)(=O)C>[CH3:34][Si:26]([CH3:33])([CH2:27][CH2:28][C:29]([F:32])([F:30])[F:31])[CH2:25][CH2:24][CH2:23][CH2:22][O:21][C:18]1[CH:19]=[N:20][C:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)=[N:16][CH:17]=1

Participants

4

Reactant 1

HCID 22717495HCID 22717495, compound

Product 1

HCID 135744189HCID 135744189, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

A suspension of compound 40 (0.321 g, 0.658 mmol), palladium on charcoal (0.0343 g, 0.033 mmol) in ethanol/ethyl acetate (6.5 ml, 1:2) was stirred under an atmosphere of hydrogen at room temperature for 24 hours. The reaction mixture was filtered (celite), the solvent removed in vacuo and the residues recrystallized from acetonitrile to yield colorless crystals.

Workup

  1. filtrationThe reaction mixture was filtered (celite)
  2. customthe solvent removed in vacuo
  3. customthe residues recrystallized from acetonitrile
  4. customto yield colorless crystals

Sources & evidence

ORD record
ord-eeabf531821547fdac9d37e2757017ae
Source dataset
uspto-grants-2004_05
Patent number
US06737124B2

Reaction notes

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