HCID 22717477, compound → HCID 22717501, compound

HRID 1582523Notes

Reaction equation

HRID 1582523 reaction equation
C([O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][Si:26]([CH3:49])([CH3:48])[CH2:27][CH2:28][C:29]([F:47])([F:46])[C:30]([F:45])([F:44])[C:31]([F:43])([F:42])[C:32]([F:41])([F:40])[C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])=[CH:17][CH:16]=2)=[N:13][CH:14]=1)C1C=CC=CC=1>[Pd].C(O)C.C(OCC)(=O)C>[CH3:49][Si:26]([CH3:48])([CH2:27][CH2:28][C:29]([F:47])([F:46])[C:30]([F:44])([F:45])[C:31]([F:42])([F:43])[C:32]([F:40])([F:41])[C:33]([F:38])([F:39])[C:34]([F:35])([F:36])[F:37])[CH2:25][CH2:24][CH2:23][CH2:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([C:12]2[N:11]=[CH:10][C:9]([OH:8])=[CH:14][N:13]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 22717477HCID 22717477, compound

Product 1

HCID 22717501HCID 22717501, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

A suspension of compound 46 (2.232 g, 3.02 mmol), palladium on charcoal (0.095 g, 0.091 mmol) in ethanol/ethyl acetate (6.5 ml, 1:2) was stirred under an atmosphere of hydrogen at room temperature for 24 hours. The reaction mixture was filtered (celite), the solvent removed in vacuo and the residues recrystallized from acetonitrile to yield colorless crystals.

Workup

  1. filtrationThe reaction mixture was filtered (celite)
  2. customthe solvent removed in vacuo
  3. customthe residues recrystallized from acetonitrile
  4. customto yield colorless crystals

Sources & evidence

ORD record
ord-35f1eaeed6b94c3a8078dd6ec2b0b115
Source dataset
uspto-grants-2004_05
Patent number
US06737124B2

Reaction notes

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