Hydrochloric Acid → HCID 22717670, compound

Participants

Reaction Steps

2-Amino-5-thiocyanato-4-trifluoromethylthiazole (0.8 g) was dissolved in pyridine (5 ml) and 3-trifluoromethylbenzoylchloride (0.8 g) was added at room temperature with stirring. The mixture was stirred for one night at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The chloroform layer was dried over magnesium sulfate and the solvent was removed under reduced pressure. The solid thus obtained was recrystallized from carbon tetrachloride to give N-(5-thiocyanato-4-trifluoromethylthiazol-2-yl)-3-trifluoromethylbenzamide (0.8 g), m. p. 167-168° C.

Provenance & Evidence