Hydrochloric Acid → HCID 22718141, compound

Participants

Reaction Steps

1.4 g (8.9 mmol) of 4-methoxycyclohexanecarboxylic acid were dissolved in 30 ml of tetrahydrofuran and, at 0° C., successively 1.9 g (1.8 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide×hydrochloride, 1.8 g (11.6 mmol) of N-hydroxybenzotriazole and 1.95 g (19.2 mmol) of triethylamine were added. The mixture was stirred for 1 hour. Then 2.0 g (8.9 mmol) of 2,3-diaminobenzamide×2 hydrochloride and 1.95 g (19.2 mmol) of triethylamine were added. The mixture was then stirred at 0° C. for 1 hour and at room temperature for 16 hours. The mixture was diluted with a large amount of water and extracted several times with ethyl acetate. The organic phases were combined, dried and concentrated in vacuo. 1.5 g of the product were obtained.

Provenance & Evidence