4-hydroxypiperidine-4-carboxylic Acid → Ethyl 4-hydroxypiperidine-4-carboxylate

HRID 1582607Notes

Reaction equation

HRID 1582607 reaction equation
[OH:1][C:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.[CH2:12](O)[CH3:13]>>[OH:1][C:2]1([C:8]([O:10][CH2:12][CH3:13])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 44371984-hydroxypiperidine-4-carboxylic AcidHCID 21887872Ethanol hydrochloride

Product 1

HCID 22717992Ethyl 4-hydroxypiperidine-4-carboxylate

Procedure

The 4-hydroxypiperidine-4-carboxylic acid (118 mg) obtained in the step (a) of Example 68 was dissolved in 1 N hydrochloric acid/ethanol (5 ml) solution, and the resulting solution was stirred at room temperature for 17 hours and then under reflux for 6 hours. The reaction mixture was concentrated to obtain crude ethyl 4-hydroxypiperidine-4-carboxylate. This crude ethyl 4-hydroxypiperidine-4-carboxylate was used in the following reaction without purification.

Workup

  1. temperatureunder reflux for 6 hours
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-b2c1e6ae0c8a4a30a8b5b1d02d2f2c79
Source dataset
uspto-grants-2004_05
Patent number
US06737416B2

Reaction notes

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