HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-chloro-2-hydroxyphenyl)-2-(1H-1-imidazolyl)-1-ethanone → 4-chloro-2-(1-cyclopropyl-1-hydroxy-2-(1H-1-imidazolyl)ethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-chloro-2-hydroxyphenyl)-2-(1H-1-imidazolyl)-1-ethanone | HCID 12953655 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Product | 4-chloro-2-(1-cyclopropyl-1-hydroxy-2-(1H-1-imidazolyl)ethyl)phenol | HCID 12972899 | 36% |
Reaction Steps
The general procedure of Example 1 was repeated using 1-(5-chloro-2-hydroxyphenyl)-2-(1H-1-imidazolyl)-1-ethanone [compound (5-1)] and cyclopropylmagnesium bromide, to thereby yield 4-chloro-2-(1-cyclopropyl-1-hydroxy-2-(1H-1-imidazolyl)ethyl)phenol as colorless crystals (yield: 36.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06737434B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-deb03407d5254315b5fc3afd16f8759d |
| Source note | uspto-grants-2004_05 |