HCID 22718709, compound → HCID 12972900, compound

HRID 1582620Notes

Reaction equation

HRID 1582620 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:16])=[C:6]([C:8](=[O:15])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH:7]=1.[CH3:17][Mg]Br>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:16])=[C:6]([C:8]([OH:15])([CH3:17])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH:7]=1

Participants

3

Reactant 2

HCID 22718709HCID 22718709, compound2×HCID 178418573HCID 178418573, compound

Product 1

HCID 12972900HCID 12972900, compoundYield 53.2%

Procedure

The general procedure of Example 1 was repeated using 1-(5-fluoro-2-hydroxyphenyl)-2-(1H-1-imidazolyl)-1-ethanone [compound (5-2)] and methylmagnesium bromide, to thereby yield 4-fluoro-2-(1-hydroxy-2-(1H-1-imidazolyl)-1-methylethyl)phenol as colorless crystals (yield: 53.2%).

Sources & evidence

ORD record
ord-7bf79752cce44fadb5de2ba5091c6e89
Source dataset
uspto-grants-2004_05
Patent number
US06737434B2

Reaction notes

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