2,4-Dichlorobenzyl chloride → HCID 12972908, compound

HRID 1582625Notes

Reaction equation

HRID 1582625 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([OH:17])([CH3:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1.[Cl:18][C:19]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:20]=1[CH2:21]Cl>>[Cl:18][C:19]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:20]=1[CH2:21][O:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=1[C:9]([OH:17])([CH3:16])[CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 72122,4-Dichlorobenzyl chlorideHCID 12972900HCID 12972900, compound2×

Product 1

HCID 12972908HCID 12972908, compoundYield 31.6%

Procedure

The general procedure of Example 6 was repeated using 4-fluoro-2-(1-hydroxy-2-(1H-1-imidazolyl)-1-methylethyl)phenol [compound (2-4)] and 2,4-dichlorobenzyl chloride, to thereby yield 2-(2-((2,4-dichlorobenzyl)oxy)-5-fluorophenyl)-1-(1H-1-imidazolyl)-2-propanol as colorless crystals (yield: 31.6%).

Sources & evidence

ORD record
ord-d62adbcf4d614b628d6ef261c8d9c324
Source dataset
uspto-grants-2004_05
Patent number
US06737434B2

Reaction notes

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