1-Chloro-2-phenylethane → HCID 22718718, compound

HRID 1582626Notes

Reaction equation

HRID 1582626 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([OH:17])([CH3:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1.[CH2:18](Cl)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.FC1C=CC(OC2C=CC=CC=2)=C(C(O)(C)CN2C=CN=C2)C=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:4]([C:9]([OH:17])([CH3:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1

Participants

4

Reactant 3

HCID 2314961-Chloro-2-phenylethaneHCID 12972900HCID 12972900, compound2×HCID 22718716HCID 22718716, compound

Product 1

HCID 22718718HCID 22718718, compoundYield 13.4%

Procedure

The general procedure of Example 6 was repeated using 4-fluoro-2-(1-hydroxy-2-(1H-1-imidazolyl)-1-methylethyl)phenol [compound (2-4)] and phenethyl chloride, to thereby yield 2-(5-fluoro-2-(phenyloxy)phenyl)-1-(1H-1-imidazolyl)-2-propanol as a colorless oily product (yield: 13.4%).

Sources & evidence

ORD record
ord-3f29c131ca7046a38e27b6aa5c0f8ea6
Source dataset
uspto-grants-2004_05
Patent number
US06737434B2

Reaction notes

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