Imidazole → HCID 22718710, compound

Participants

Reaction Conditions

Reaction Steps

Imidazole (4.0 g, 58.8 mmol) and potassium t-butoxide (6.5 g, 57.9 mmol) were added to a solution of 2-(2-(benzyloxy)-5-chlorophenyl)-2-methyloxirane [compound (10-1), obtained in Referential Example 8] (4.4 g) in dimethylformamide (60 mL), and the mixture was stirred for 12 hours at 80° C. After the mixture was cooled to room temperature, ice-water was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with water and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified through silica gel column chromatography and dried under reduced pressure, to thereby yield 2-(2-(benzyloxy)-5-chlorophenyl)-1-(1H-1-imidazolyl)-2-propanol as colorless crystals (5.0 g, yield: 75.8%).

Provenance & Evidence