HCID 22718719, compound → HCID 22718746, compound

Participants

Reaction Steps

A mixture of methyl-N-(3,4-dichlorobenzyl)-4-fluoro-5-benzyloxyindole-2-carboxylate (8.22 g) and 5% Pd/C (200 mg) in ethyl acetate (250 ml) was stirred under a hydrogen atmosphere overnight, filtered through celite, concentrated in vacuo and purified by flash column chromatography using a gradient of 0-50% ethyl acetate/iso-hexane as eluent to give the product as a brown solid (6.18 g) 1H NMR (DMSO-d6) δ3.80(s, 3H), 5.75(s, 2H), 6.85(m, 1H), 7.00(t, 1H), 7.22(m, 2H), 7.30(m, 1H), 7.50(m,1H), 9.33(s, 1H); M/z(−) 366.2 (MH−)

Provenance & Evidence