Methanol → HCID 22718730, compound

Participants

Reaction Steps

Trimethylsilyliodide (0.6 ml) was added to a solution of ethyl-N-(3,4-dichlorobenzyl)-4-chloro-5-methoxyindole-2-carboxylate (190 mg) in chloroform (20 ml). The mixture was heated to 50 C. for 18 hours then poured into methanol (50 ml) and concentrated under vacuo. The residue was purified by column chromatography using isohexane-20% ethyl acetate/isohexane as eluent to yield the product as a yellow solid (100 mg,71%) NMR: δ (CDCl3) 1.39 (t, 3H), 4.35 (q, 2H), 5.72 (s, 2H), 6.84 (dd, 1H), 7.05-7.13 (m, 3H) 7.3 (d, 1H) 7.35 (s, 1H);m/z396.2/398.2 (M−H+)

Provenance & Evidence