反应详情

To a solution of ethyl 3-hydroxy-3-([1,1′-biphenyl]-4yl)-butanoate (2e, 11 g) in benzene (250 ml) was added phosphorus pentoxide (4 g) and refluxed for 3 h. The benzene layer was decanted and then concentrated. The crude product was purified by column chromatography on silica gel to furnish 11 g (57.3% yield) of ethyl 3-([1,1′-biphenyl]-4yl)-but-2-enoate (3e, formula 3, R=Ph) m.p. 76-78° C.

1. temperaturerefluxed for 3 h
2. customThe benzene layer was decanted
3. concentrationconcentrated
4. customThe crude product was purified by column chromatography on silica gel