Methanol → 1-(2,4-Dihydroxy-3-Prenylphenyl)-3-(4-Hydroxyphenyl)Propane

反応式

[Na+].[Cl-].[CH3:3][C:4]([CH3:28])=[CH:5][CH2:6][C:7]1[CH:8]=[C:9]([C:14]2O[C:23]3[CH:22]=[C:21]([OH:25])[CH:20]=[C:19](O)[C:18]=3[C:16](=O)[C:15]=2O)[CH:10]=[CH:11][C:12]=1[OH:13].C[OH:30]>>[OH:30][C:8]1[C:7]([CH2:6][CH:5]=[C:4]([CH3:28])[CH3:3])=[C:12]([OH:13])[CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][C:18]1[CH:19]=[CH:20][C:21]([OH:25])=[CH:22][CH:23]=1

参加物

反応物 3

HCID 887Methanol

HCID 5234Sodium Chloride

HCID 5318585Isolicoflavonol

生成物 1

HCID 109139751-(2,4-Dihydroxy-3-Prenylphenyl)-3-(4-Hydroxyphenyl)Propane

実験手順

Brown powder; mp 115-116° C.; UV (MeOH) λmax (log ε) 279 (3.28), 232 (3.55) nm; IR (NaCl) γmax 3421, 2909, 1652, 1515 cm−1; 1H and 13C NMR data, see Table 3; HMBC correlations: H-1/C-1′, C-21, C-61; H-2/C-1′, C-1″; H-3/C-1″, C-2″; H-5′/C-1′, C-3′, C-4′; H-6′/C-1, C-2′, C-4′; H-2″/C-3, C-1″, C-4″; H-3″/C-1″, C-4″; H-1′″/C-2′, C-41; H-4′″ and H-5′″/C-2′″, C-3′″; EIMS m/z 312 (M+, 67), 257 (12), 191 (100), 135 (74); HREIMS m/z 312.1725, calcd for C20H24O3, 312.1725.

出典と根拠

ORDレコード: ord-1f075c141e314a73b6c320df6a4da868
出典データセット: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06737439B2

反応ノート

読み込み中…