Trifluoroacetic acid → HCID 86587441, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-(1-methylsulfanyl-2-phenethylcarbamoyl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.15 g, 2.93 mmol) in CH2Cl2 (3 ml) was added TFA at 0° C. After being stirred at 0° C. for 30 min, the mixture was evaporated in vacuo to give 3-methylsulfanyl-N-phenethyl-3-pyrrolidin-2-yl-propionamide TFA salt as a crude oil (1.87 g), which was used without further purification in the next step [The diastereomers were separable by preparative HPLC (column: ODS-80Ts, eluent: 79/21 H2O:CH3CN/0.05% TFA)].

Provenance & Evidence