HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 2-[2-(Piperazin-1-yl)ethoxy]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Hydroxybenzonitrile | HCID 11907 | — |
| Reactant | 4-(2-Hydroxyethyl)piperazine-1-carbaldehyde | HCID 9942213 | — |
| Reactant | Diethylazodicarboxylate toluene | HCID 66777355 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[2-(Piperazin-1-yl)ethoxy]benzonitrile | HCID 22718306 | 23.1% |
Reaction Steps
1-Formyl-4-(2-hydroxyethyl)piperazine (4.95 g) was dissolved in tetrahydrofuran (100 ml), then triphenyl phosphine (10.14 g) and 2-cyanophenol (3.57 g) were added thereto, and 40% azodicarboxylic acid diethyl ester/toluene solution (13.5 ml) was added dropwise thereto, and the title compound (1.60 g) was obtained in the same manner as in Example 47-1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06737425B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-5333d02393e34efcbad9222b7174a98c |
| Source note | uspto-grants-2004_05 |