Triethylamine → HCID 22718211, compound

Participants

Reaction Steps

2-Chloroethyl-4-fluorophenyl sulfone (2.5 g), N-(t-butoxycarbonyl)piperazine (2.3 g) and triethylamine (1.7 ml) were dissolved in tetrahydrofuran (30 ml) and stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water, dried, and evaporated. The residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system) to give the title compound (4.4 g, quantitatively) as a colorless oil.

Provenance & Evidence