Methanol → Ethyl 2-(4-amino-3-(2,2,2-trifluoroethoxy)phenyl)-4-methylpentanoate

HRID 158275Notes

Reaction equation

HRID 158275 reaction equation
[CH3:1][CH:2]([CH2:3][CH:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[c:10]1[cH:11][c:12]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[c:13]([N+:16]([O-:17])=[O:18])[cH:14][cH:15]1)[CH3:25].[CH3:26][OH:27].[OH-:28].[OH-:29].[Pd+2:30]>>[CH3:1][CH:2]([CH2:3][CH:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[c:10]1[cH:11][c:12]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[c:13]([NH2:16])[cH:14][cH:15]1)[CH3:25]

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57995623Ethyl 4-methyl-2-(4-nitro-3-(2,2,2-trifluoroethoxy)phenyl)pentanoate

Product 1

HCID 57995581Ethyl 2-(4-amino-3-(2,2,2-trifluoroethoxy)phenyl)-4-methylpentanoate

Sources & evidence

ORD record
ord-4e918c39f65944619e7c816555b05ca0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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