Boron tribromide → HCID 22718253, compound

Participants

Reaction Steps

1-[4-Cyano-5-methyl-4-(4-methoxyphenyl)hexyl]-4-[2-(4-fluorophenoxy)ethyl]piperazine 85 mg obtained in Example 11 was dissolved in dichloromethane 3 ml, and 1M-boron tribromide (dichloromethane solution, 0.5 ml) was added dropwise thereto under ice-cooling. After haeting the mixture under reflux for 5 hours, it was cooled to room temperature and basified with aqueous saturated sodium bicarbonate under ice-cooling. The mixture was extracted with ethyl acetate, and the organic layer was washed with water, dried over sodium sulfate anhydride, and evaporated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound 30 mg, 36% was obtained as a colorless oil.

Provenance & Evidence