N-Cyclohexylaniline → 2-(Cyclohexylphenylamino)ethanol

HRID 1582758Notes

Reaction equation

C([O:3][C:4]([CH2:6][N:7]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)C.C1(NC2C=CC=CC=2)CCCCC1>>[CH:14]1([N:7]([CH2:6][CH2:4][OH:3])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

Reactant 2

HCID 74567N-Cyclohexylaniline

HCID 12646772HCID 12646772, compound

Product 1

HCID 833872-(Cyclohexylphenylamino)ethanolYield 42%

Procedure

N-ethoxycarbonylmethyl-N-cyclohexyl aniline 1.89 g was obtained from N-cyclohexyl aniline 1.30 g in the same manner as in the above example. This product 860 mg was reduced to give the title compound (300 mg, 42%).

Sources & evidence

ORD record: ord-12fbbaa6e32241d587f92ac37f2a3e9d
Source dataset: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06737425B1

Reaction notes

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