1-Chloroethyl chloroformate → HCID 22718220, compound

Participants

Reaction Steps

1-Benzyl-4-[2-(4-fluorophenoxy)butyl]piperazine 717 mg was dissolved in dichloroethane 10 ml, and 1-chloroethyl chloroformate 598 mg was added thereto, and the mixture was stirred for 2 hours under reflux with heating. After the reaction mixture was concentrated, methanol 10 ml was added thereto, and the mixture was stirred for 1 hour under reflux with heating. After the mixture was evaporated, it was partitioned by adding ether and 2N hydrochloric acid, and the aqueous layer was neutralized with 2N sodium hydroxide followed by extracting with ethyl acetate. The organic layer was washed with water and brine successively, dried over magnesium sulfate anhydride and evaporated, whereby the title compound 168 mg, 32% was obtained as a colorless oil.

Provenance & Evidence