2-Bromoethanol → 2-(3-BroMo-phenoxy)-ethanol

Participants

Reaction Conditions

Reaction Steps

In a nitrogen atmosphere, 3-bromophenol 5.0 g, 2-bromoethanol 5.42 g, and potassium carbonate 12.0 g were added to N,N-dimethylformamide 30 ml, and the mixture was stirred at 100° C. After 1 hour, the reaction mixture was cooled to room temperature and partitioned by adding water and diethyl ether. The organic layer was washed with water and then with brine, dried over magnesium sulfate anhydride and evaporated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound (4.85 g, 77%) was obtained as a colorless oil.

Provenance & Evidence