HCID 22718039, compound → HCID 22718017, compound

HRID 1582807Notes

Reaction equation

HRID 1582807 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:40]=[CH:39][C:15]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([CH2:29][CH2:30][CH2:31][C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])(C(O)=O)[C:23]([OH:25])=[O:24])=[CH:14][CH:13]=3)=[O:11])=[C:8]([C:41]3[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=3)[S:7][C:6]=2[CH:48]=1>CS(C)=O.O>[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:40]=[CH:39][C:15]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]([CH2:29][CH2:30][CH2:31][C:32]([F:38])([F:37])[C:33]([F:34])([F:35])[F:36])[C:23]([OH:25])=[O:24])=[CH:14][CH:13]=3)=[O:11])=[C:8]([C:41]3[CH:42]=[CH:43][C:44]([OH:47])=[CH:45][CH:46]=3)[S:7][C:6]=2[CH:48]=1

Participants

4

Reactant 1

HCID 22718039HCID 22718039, compound

Product 1

HCID 22718017HCID 22718017, compoundYield 71.2%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

2-[5-[4-[(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]-thiophen-3-yl)carbonyl]-phenoxy]pentyl]-2-(4,4,5,5,5-pentafluoropentyl)malonic acid (1.1 g, 1.58 mmol) was dissolved in dimethyl sulfoxide (10 ml) and stirred for 3 hours at 120° C. The reaction mixture was cooled to room temperature, diluted with water, and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1/1) to give 2-[5-[4-[(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)carbonyl]phenoxy]-pentyl]-6,6,7,7,7-pentafluoroheptanoic acid (732 mg, Yield 71%) as a yellow solid.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customthe resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1/1)

Sources & evidence

ORD record
ord-6b7355d1459a4d1eaf7ebda30fe0a056
Source dataset
uspto-grants-2004_05
Patent number
US06737417B2

Reaction notes

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