Ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoate → 10-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoate	HCID 22718078	—
Reactant	3-Methoxy-7alpha-(2-propenyl)estra-1,3,5(10)-trien-17beta-ol	HCID 69414807	—
Product	10-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid	HCID 86588530	—

Reaction Steps

Starting with the 3-methoxy-7α-(2-propenyl)estra-1,3,5(10)-trien-17β-ol prepared in Example 13 and ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 10-[3,17β-dihydroxyestra-1,3,5(10)-trien-7α-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06737417B2
Source dataset	uspto-grants-2004_05
ORD ID	ord-8f5dcdbc741b446fa9072496e50f1e28
Source note	uspto-grants-2004_05