Hydrochloric Acid → HCID 21866455, compound

Participants

Reaction Steps

19 g (105.42 mmol) of 5-cyano-3,4-dimethylthiophene-2-carboxamide were suspended in 760 ml of methanol and 110 ml of 2N hydrochloric acid solution, 9.5 g of Pd on charcoal (10%) were added, and the mixture was hydrogenated at room temperature. After 4.71 of hydrogen had been taken up (4 h), methanol was distilled out in vacuo, and the aqueous phase was extracted three times with ethyl acetate and subsequently freeze-dried. 16.3 g of the required product resulted as a white solid (70.4% of theory).

Provenance & Evidence